Large-scale admixture mapping in the All of Us Research Program improves the characterization of cross-population phenotypic differences
Ravi Mandla, Zhuozheng Shi, Kangcheng Hou, Ying Wang, Georgia Mies, Alan J. Aw, Sinéad Cullina, Penn Medicine BioBank, Alan Aw, Eimear E. Kenny, Iain Mathieson, Elizabeth G. Atkinson, Alicia R. Martin, Bogdan Paşaniuc
The paper uses admixture mapping in the All of Us Research Program to identify genetic ancestry associations with 22 traits, finding 71 novel loci where African ancestry explains phenotypic variation.
Nature Communications · Aug 12, 2026Peer-reviewedGenetic & Genomic Medicine