Full-Length Context Disrupts Folding of IgG-Binding Domains of Protein A
Kosar Rahimi, Albert Halbing, Minh Ngoc Nguyen, Mehmet Şen, Richard C. Willson, Gül H. Zerze
The paper shows that full-length Staphylococcal protein A fails to fold stably despite its individual domains being stable, challenging assumptions about modular protein folding and AI prediction accuracy.
bioRxiv · Dec 9, 2025 · PreprintBiophysics