Systematic characterization of protein structural features of alternative splicing isoforms using AlphaFold 2
Yuntao Yang, Yuhan Xie, Li Zhao, Chiamaka S Diala, Meer Akbar Ali, Rongbin Li, Yi Xu, Albon Wu, Pora Kim, Sayed‐Rzgar Hosseini, Erfei Bi, Hongyu Zhao, Wenjin Jim Zheng
This study uses AlphaFold 2 to analyze the structural impact of alternative splicing in 3,000 human genes, identifying structural changes and disease-related mutations.
bioRxiv · Jan 30, 2024 · PreprintBioinformatics