Valve endothelial monolayer fissuring via RhoA activity induces 3D calcific aortic valve lesion emergence as revealed by a longitudinal live-imaging platform
Katherine Driscoll, Santosh Balakrishnan, G. Janani, Hrishika Gogineni, Alessandra Good, Andrea Huang, Nichaluk Leartprapun, Steven G. Adie, Jonathan Talbot Butcher
This paper develops a live-imaging platform to study calcific aortic valve disease onset and identifies RhoA activity as a key driver of lesion formation.
bioRxiv · Jun 21, 2025 · PreprintBioengineering