Cancer BiologybioRxivPreprint
Opposing immune and genetic forces shape oncogenic programs in synovial sarcoma
Livnat Jerby-Arnon, Cyril Neftel, Marni E. Shore…·Aviv Regev
The paper profiles synovial sarcoma tumors to show that the SS18-SSX fusion drives oncogenic programs, which are repressed by immune cells and can be targeted with HDAC and CDK4/6 inhibitors.