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This study identifies chemical compounds that enhance MHC class I antigen presentation of cancer neoantigens by stabilizing peptide-MHC complexes.

This study shows macroH2A limits EBV replication by restricting H2A.Z and EBNA1 binding at oriP, reducing DNA damage signaling and episomal replication.

This study evaluates a multimodal ctDNA detection approach in pediatric CNS tumors, finding improved detection rates in CSF compared to plasma and associations with survival outcomes.

This study shows mRNA-LNP vaccination remodels the glioblastoma microenvironment and generates tissue-resident memory T cells, leading to durable tumor control.

This study maps the epigenomic circuits in pleural mesothelioma, identifies potential transcription factors and regulatory elements, and suggests their relevance to epigenetic editing strategies.

This study examines how Pyridostatin and TMPyP4 affect microRNA regulation in HeLa cells exposed to ionizing radiation.

This study identifies a metabolic vulnerability in NRF2-hyperactive cancers where selenite induces cell death by disrupting mitochondrial function and redox balance.

This paper identifies three therapeutic axes for MBD4-deficient tumors using a multi-layered framework, showing sensitivity to ATR inhibitors and cytidine analogs but not PARP inhibitors.

This study shows that Tet2-mutant clonal hematopoiesis promotes while Dnmt3a-mutant clonal hematopoiesis inhibits breast cancer progression with age, identifying IL-1/CXCL2 inflammation as a therapeutic target.

This study identifies S100A4 as a targetable regulator of immune suppression in glioblastoma, showing its inhibition enhances immunotherapy response and survival.

This paper identifies a SOX9 C-terminal module that recruits cBAF to enhancers, controlling cell state by remodeling chromatin.

The paper identifies retained-region transcript architectures and region-dependent nucleolar enrichment of lncRNAs in colorectal cancer using integrated multi-omics approaches.

The paper identifies NPM1::ALK-derived circular RNAs that promote aggressiveness in ALK-positive anaplastic large cell lymphoma by modulating cytokine signaling and myeloid remodeling.

The paper identifies LCK-driven EGFR activation as a therapeutic target in cholangiocarcinoma, showing EGFR activity predicts response to EGFR inhibition.

This study uses AI to identify BMI-associated morphologic features in breast cancer tissue, finding that high BMI is linked to distinct stromal patterns and reduced inter-patient heterogeneity.

This study characterizes the neuroblastoma immune microenvironment, finding limited T cell infiltration, abundant macrophages with targetable receptors, and associations between immune composition and patient survival.

This study identifies methylene blue as a modulator of G3BP1 condensation that reduces preneoplastic lesions in Kras-driven pancreatic cancer models.

This study compares tumor-immune-stromal communication in plasmacytoid urothelial carcinoma (PUC) and conventional urothelial carcinoma (CUC) using single nucleus RNA sequencing and spatial transcriptomics, identifying distinct signaling patterns and potential therapeutic targets.