Mathematical modeling and sensitivity analysis of synNotch-CAR T-cells identify engineering targets for dynamic tunability
Alexander Diefes, Bashir Sbaiti, Maria-Veronica Ciocanel, Cameron M. Kim
The paper develops mathematical models of synNotch-CAR T-cells and performs sensitivity analysis to identify parameters that can be engineered for dynamic tunability in cancer therapeutics.
Mathematical Biosciences & Engineering · Jan 1, 2026Peer-reviewedSynthetic Biology