Age-related and heteroplasmy-related variation in human mtDNA copy number
Manja Wachsmuth, Alexander Huebner, Mingkun Li, Burkhard Madea, Mark Stoneking
This study examines mtDNA copy number variation across tissues and age, finding age-related decreases in skeletal muscle and increases in liver, with heteroplasmic sites linked to mtCN changes in muscle.
PLOS Genetics · Mar 15, 2016Peer-reviewedEvolutionary Biology