Beyond power: Multivariate discovery, replication, and interpretation of pleiotropic loci using summary association statistics
Ning Zheng, Yakov A. Tsepilov, Sodbo Sharapov, Alexander K. Grishenko, Xiao Feng, Masoud Shirali, Peter K. Joshi, James F. Wilson, Yudi Pawitan Y, Chris Haley, Yurii S. Aulchenko, Xia Shen
This paper develops a multi-trait framework for discovering, replicating, and interpreting pleiotropic loci using GWAS summary statistics, identifying novel genetic associations without additional genotyping.
bioRxiv · Apr 11, 2019 · PreprintGenetics