Beyond synthetic lethality: charting the landscape of clinically relevant genetic interactions in cancer
Assaf Magen, Avinash D Sahu, Joo Sang Lee, Mahfuza Sharmin, Alexander Lugo, Jorge Silvio Gutkind, Alejandro A. Schäffer, Eytan Ruppin, Sridhar S. Hannenhalli
The paper identifies 71,946 genetic interactions in cancer using a novel method, revealing non-synthetic-lethal interactions that explain driver gene specificity and drug response.
Cell Reports · Jul 1, 2019Peer-reviewedSystems Biology