Glioma-derived M-CSF and IL-34 license M-MDSCs to suppress CD8+ T cells in a NOS-dependent manner
Gregory Pal Takacs, Julia S. Garcia, Caitlyn A. Hodges, Christian J. Kreiger, Alexandra Sherman, Jeffrey K. Harrison
This study identifies M-CSF and IL-34 as drivers of M-MDSC differentiation and T cell suppression in glioblastoma, with NOS involvement and microenvironmental niches contributing to M-MDSC heterogeneity.
Cancers · Sep 1, 2024Peer-reviewedCancer Biology