Deep learning analyses of DNA sequences resolve the retention of the Duffy-null resistance to Plasmodium vivax malaria in Africa
Guillaume Laval, Alice Decugis, Oğuzhan Parasayan, Étienne Patin, Lluís Quintana‐Murci, Jacques Chiaroni
The paper uses deep learning to analyze DNA sequences and shows that the Duffy-null allele, protective against P. vivax, was retained in Africa due to selection pressures, with evidence of its spread linked to the Bantu expansion.
bioRxiv · Dec 26, 2025 · PreprintEvolutionary Biology