Architectonic Spandrels in the Origin of Enzymatic Function
Miriam Poley-Gil, Miguel Fernandez-Martin, Alin Banka, Michael Heinzinger, Burkhard Rost, Alfonso Valencia, R. Gonzalo Parra
The paper investigates whether functional frustration in proteins is an evolutionary adaptation or a byproduct of fold architecture, finding that frustration hotspots are inherent physical constraints co-opted for function.
bioRxiv · Sep 3, 2026 · PreprintBioinformatics