DNA methylation effects on Van der Woude Syndrome phenotypic variability
Amanda Seaberg, Waheed A. Awotoye, Fang Qian, Ligiane Alves Machado‐Paula, Lindsey Dunlay, Azeez Butali, Jeffrey C. Murray, Lina M. Moreno‐Uribe, Aline Lourenço Petrin
The paper investigates DNA methylation differences in IRF6 and TP63 regulatory regions in Van der Woude Syndrome patients and finds hypermethylation in IRF6 promoters correlates with more severe phenotypes.
The Cleft Palate-Craniofacial Journal · Aug 7, 2024Peer-reviewedGenetic & Genomic Medicine