Genome-wide profiling of highly similar paralogous genes using HiFi sequencing
Xiao Chen, Daniel Baker, Egor Dolzhenko, Joseph M. Devaney, Jessica Noya, April S. Berlyoung, Rhonda C. Brandon, Kathleen S. Hruska, Lucas Lochovsky, Paul S. Kruszka, Scott Newman, Emily Farrow, Isabelle Thiffault, Tomi Pastinen, Dalia Kasperavičiūtė, , Michael A. Eberle
The paper develops Paraphase, a HiFi-based method to resolve highly similar paralogous genes, revealing genetic diversity and de novo events in segmental duplications.
Nature Communications · Mar 8, 2025Peer-reviewedGenomics