Mixture models reveal multiple positional bias types in RNA-Seq data and lead to accurate transcript concentration estimates
Andreas Tuerk, Gregor Wiktorin, Serhat Güler
The paper introduces Mix2, a model that improves RNA-Seq transcript quantification by accounting for positional fragment bias, leading to more accurate abundance estimates and better differential expression detection.
bioRxiv · Nov 24, 2014Bioinformatics