Ancestral evolution of oxidase activity in a class of (S)-nicotine and (S)-6-hydroxynicotine degrading flavoenzymes
Zhiyao Zhang, Parth R Bandivadekar, Andrew J. Gaunt, Surl-Hee Ahn, Todd J. Barkman, Frederick W. Stull
This study traces the evolutionary emergence of oxidase activity in nicotine-degrading flavoenzymes by identifying key amino acid changes and their structural impacts.
Journal of Biological Chemistry · Jun 11, 2025Peer-reviewedBiochemistry