Altered neutrophil G-protein receptor signalling linked to impaired chemotaxis and increased ROS and NET production in older people with frailty
Genna Ali Abdullah, Jack Walsh, Andrew Sellin, Cody McLean, Asangaedem Akpan, Marie M Phelan, Helen L Wright
This study identifies altered G-protein receptor signalling in frailty neutrophils, linked to impaired chemotaxis and increased ROS/NET production compared to healthy older individuals.
medRxiv · Dec 17, 2025 · PreprintGenetic & Genomic Medicine