Functional impact of the hyperduplication genomophenotype in high copy number endometrial cancer
Angela B. Florio, James B. Smadbeck, Sarah H. Johnson, Wan‐Hsin Lin, Dorsay Sadeghian, Sotiris Sotiriou, Rebeca Salvatori, Ryan W. Feathers, Taylor Berry, Lindsey Kinsella, Faye R. Harris, Alexa McCune, Stephen J. Murphy, Mohamed F. Ali, Abdulmohammad Pezeshki, , George Vasmatzis
The paper investigates the functional impact of the HyperDuplication GenomoPhenotype in high copy number endometrial cancer, showing it enhances tumor fitness and therapy resistance through coordinated duplication of oncogenes.
iScience · Jun 7, 2025Peer-reviewedGenomics