Dissecting the cis-regulatory syntax of transcription initiation with deep learning
Kelly Cochran, Melody Yin, Anika Mantripragada, Jacob Matthew Schreiber, Georgi K. Marinov, Sagar R Shah, Haiyuan Yu, John T. Lis, Anshul Bharat Kundaje
The paper trains a deep learning model to predict transcription initiation from DNA sequences, revealing shared cis-regulatory logic and epistatic interactions across promoters and enhancers.
bioRxiv · May 28, 2024 · PreprintGenomics