Metabolic Symbiosis between Oxygenated and Hypoxic Tumour Cells: An Agent-based Modelling Study
Pahala Gedara Jayathilake, Pedro Victori, Clara Eléonore Pavillet, Chang Heon Lee, Dimitrios Voukantsis, Ana Miar, Anjali Arora, Adrian Llewellyn Harris, Karl Morten, Francesca Meteora Buffa
This paper uses agent-based modeling to study metabolic cooperation between oxygenated and hypoxic tumor cells, finding that aerobic glycolysis provides an overall advantage and that blocking glucose transporters is more effective than lactate transporters in reducing tumor growth.
PLoS Computational Biology · Mar 15, 2024Peer-reviewedSystems Biology