Shared and distinct sequence-function signatures define different modes of human TpoR activation
Xinyu Wu, Harry McLeod, Anna Malinovitch, Sally M. Hunter, Samyuktha Ramesh, Margareta Go, Julie V. Nguyen, Alan F. Rubin, W. Bürger, Piers A. Blombery, Matthew Edwin Call, Melissa J. Call
This paper identifies shared and distinct sequence-function signatures for different modes of hTpoR activation using deep mutational scanning and AlphaFold 3 modeling.
bioRxiv · Sep 9, 2025 · PreprintBiochemistry