High side chain promiscuity of the terminal enzyme in the homologation pathway for L-phenylalanine and L-tyrosine
Rebecca M. Lang Harman, H. Grace Blackstone, Juan-Paolo Reynes, Anna Parviainen, Daniela Figueredo, Jorge Nochebuena, Shogo Mori
This study investigates the substrate promiscuity of the enzyme HphB in the homologation pathway, showing it can accept diverse side chains while maintaining backbone specificity.
bioRxiv · Jun 19, 2026 · PreprintBiochemistry