GWAS defines pathogenic signaling pathways and prioritizes drug targets for IgA nephropathy
Krzysztof Kiryluk, Elena Sánchez, Shu‐Feng Zhou, Francesca Zanoni, Lili Liu, Nikol Mladkova, Atlas Khan, Maddalena Marasà, Jun Y. Zhang, Olivia Balderes, Simone Sanna‐Cherchi, Andrew S. Bomback, Pietro A. Canetta, Gerald B. Appel, Jai Radhakrishnan, , Claudia Izzi
This study identifies 30 genome-wide significant risk loci for IgA nephropathy, links them to inflammatory pathways, and prioritizes drug targets.
medRxiv · Nov 19, 2021 · PreprintGenetic & Genomic Medicine