This study identifies 20 genome-wide significant loci associated with serum IgA levels and finds genetic correlations with various immune and metabolic traits.

Nature Communications · Nov 11, 2022Peer-reviewedGenetic & Genomic Medicine

GWAS defines pathogenic signaling pathways and prioritizes drug targets for IgA nephropathy

Krzysztof Kiryluk, Elena Sánchez, Shu‐Feng Zhou, Francesca Zanoni, Lili Liu, Nikol Mladkova, Atlas Khan, Maddalena Marasà, Jun Y. Zhang, Olivia Balderes, Simone Sanna‐Cherchi, Andrew S. Bomback, Pietro A. Canetta, Gerald B. Appel, Jai Radhakrishnan, , Claudia Izzi

This study identifies 30 genome-wide significant risk loci for IgA nephropathy, links them to inflammatory pathways, and prioritizes drug targets.

medRxiv · Nov 19, 2021 · PreprintGenetic & Genomic Medicine

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

Andrew P. Morris, Thu H Le, Hao Wu, Artur Akbarov, Peter J. van der Most, Gibran Hemani, George Davey Smith, Anubha Mahajan, Kyle J. Gaulton, Girish N. Nadkarni, Adán Valladares‐Salgado, Niels H. Wacher, Josyf C. Mychaleckyj, Nicole Dueker, Xiuqing Guo, , Nora Franceschini

This study identifies 93 genetic loci associated with kidney function across four ancestry groups and highlights causal effects on kidney-related diseases.

Nature Communications · Dec 28, 2018Peer-reviewedGenetics