RNA-ligand complexes and the attenuation of neutral confinement in the evolution of RNA secondary structures
Antonio Loreto, Edgardo Ugalde, Carlos Espinosa‐Soto
The paper models RNA evolution under ligand binding constraints, showing that RNA-ligand complex formation and thermal fluctuations prevent neutral confinement by reducing the selective advantage of highly stable structures.
Journal of The Royal Society Interface · Jul 1, 2026Peer-reviewedEvolutionary Biology