From diminishing returns to entrenchment: a unifying theory of epistasis along adaptive walks revealed by Fisher's geometric model
Arnaud Maillard, Maillard Arnaud, Ilan Coeuille, Olivier Tenaillon
This paper uses Fisher's geometric model to show that epistasis along adaptive walks can be classified into diminishing returns, contingency, and entrenchment based on phenotypic complexity and selection pressure.
bioRxiv · May 11, 2026 · PreprintEvolutionary Biology