Synapse-related protein alterations and estradiol deficiency associate with early Parkinsonism in female A53T-α-synuclein transgenic mice fed on a high-fat diet
Swati Aggarwal, Ankit Biswas, Naman Kharbanda, Nitu Singh, Krishna Singh Bisht, Chandrayee Dey, Saloni Khatri, Arundhati Tiwari, Tushar Kanti Maiti
This study shows that a high-fat diet accelerates Parkinson's-like symptoms in female mice, linked to synapse damage and low estradiol, while males show immune pathway changes.
bioRxiv · Oct 22, 2025 · PreprintNeuroscience