Plasma Extracellular Vesicle Lipidomics Reveals an SMPD1-Driven Sphingomyelin Salvage Pathway Collapse in Parkinson's Disease
Sanskriti Rai, Astha Chaubey, Sangita Paul, Sadaqa Zehra, Ananya, Roopa Rajan, Shashank Shekhar, Jagadeshwar Reddy.T, Suman Jain, Sarika Gupta, Krishna Kishore Inampudi, Neerja RANI, Anita Mahadevan, Gyan Prakash Modi, Saroj Kumar
The paper identifies SMPD1-driven disruption of the ceramide-sphingomyelin axis in Parkinson's disease using plasma extracellular vesicle lipidomics and validates findings across multiple models.
bioRxiv · Sep 28, 2026 · PreprintNeuroscience