Epi-mutations for spermatogenic defects by maternal exposure to Di (2-ethylhexyl) phthalate
Yukiko Tando, Hitoshi Hiura, Asuka Takehara, Yumi Ito‐Matsuoka, Takahiro Arima, Yasuhisa Matsui
This study shows maternal exposure to DEHP causes DNA hypermethylation in spermatogenesis-related genes in fetal germ cells, leading to gene downregulation and spermatogenic defects in F1 mice.
eLife · Jul 28, 2021Peer-reviewedDevelopmental Biology