Chaos Game Representation: An Alignment-Free Technique for Exploring Evolutionary Relationships of Protein Sequences
Priyasma Bhoumik, Austin L. Hughes
The paper introduces a method using Chaos Game Representation to explore evolutionary relationships of protein sequences and finds that it clusters viral families but resolves group relations less effectively than alignment-based phylogeny.
bioRxiv · Mar 5, 2018 · PreprintEvolutionary Biology