Epigenetic conditioning improves sequence-based modeling of gene regulation across cell types and alleles
Oberon Dixon-Luinenburg, Ayesha Bajwa, Mitchell Robert Vollger, Andrew Stergachis, Aaron Streets, Nilah M. Ioannidis
This paper introduces MethylSeqNet, a model that improves sequence-based gene regulation predictions by conditioning on CpG methylation, showing benefits for cell-type-specific regulation and allele-specific phenomena.
bioRxiv · Jun 7, 2026 · PreprintGenomics