Sensitive detection of highly fragmented cytomegalovirus nucleic acid in human cfDNA
V. Peddu, B. Bradley, S. Shree, B. Colbert, H. Xie, T. Santo, M. Huang, E. Cheng, E. Konnick, S. Salipante, K. Jerome, C. Lockwood, A. L. Greninger
The paper detects highly fragmented CMV nucleic acid in maternal cfDNA and shows its distinct fragment length distribution compared to human cfDNA, which may explain discrepancies in qPCR measurements.
bioRxiv · Aug 28, 2019 · PreprintMicrobiology