Spatial proteomics on repurposed sequencers reveals early astrocytic remodeling in an ALS mouse model
K. Pandit, C. Fouts, S. Rodwin, S. Maniatis, K. Dhingra, S. Marrakchi, D. Domovic, J. Singh, B. Dumitrascu, H. Phatnani, M. Pleska, Sanja Vickovic
The paper develops a spatial proteomics workflow to study early astrocytic remodeling in an ALS mouse model, finding that motor neurons are surrounded by GFAP-high environments earlier than previously observed.
bioRxiv · Nov 10, 2026 · PreprintNeuroscience