High-resolution portability of 245 polygenic scores when derived and applied in the same cohort
F. Prive, H. Aschard, S. Carmi, L. Folkersen, C. Hoggart, P. F. O'Reilly, B. J. Vilhjalmsson
This study evaluates the portability of polygenic scores within the same cohort across nine ancestry groups, showing reduced accuracy with increasing genetic distance.
The American Journal of Human Genetics · Jan 1, 2022Peer-reviewedGenetic & Genomic Medicine