Ultra-deep sequencing reveals intra-host diversity and co-infection-driven evolution of SARS-CoV-2
Carol Moraga, Francisco Kirhman, Barbara Bernal, Sofia Poblete, Pastor Jullian, Adrian Gonzalez, Mauricio Latorre, Alex Di Genova
This study uses ultra-deep sequencing to analyze intra-host SARS-CoV-2 diversity and co-infection-driven evolution in Chilean patients, finding increased genetic diversity and positive selection in the Spike gene during co-infections.
bioRxiv · Jan 19, 2026 · PreprintGenetics