BOLD signal changes can oppose oxygen metabolism across the human cortex
Samira Maria Epp, Gabriel Castrillón, Beijia Yuan, Jessica R. Andrews‐Hanna, Christine Preibisch, Valentin Riedl
The paper shows that BOLD signal changes can oppose oxygen metabolism in 40% of voxels, particularly in the default mode network, challenging the canonical interpretation of fMRI.
Nature Neuroscience · Dec 16, 2025Peer-reviewedNeuroscience