Spatially-resolved Photoproximity Profiling of MYC Identifies a MYC-BAF Liability in Cancer Cells
Anthony J. Carlos, Shuyuan Huang, Dongbo Yang, Colin Swenson, Pratyasha Chakraborty, Shaopeng Yu, Benjamin D. Stein, Raymond E. Moellering
This paper introduces siPROX, a spatially resolved photoproximity method to map MYC interactomes, revealing BAF complex interactions as a therapeutic target in MYC-driven cancers.
bioRxiv · Oct 17, 2025 · PreprintCancer Biology