Inhibition of histone deacetylase 1 or 2 reduces microglia activation through a gene expression independent mechanism.
Benjamin S. Durham, Ronald Grigg, Ian C. Wood
This study shows that inhibiting HDAC1 or HDAC2 reduces microglia activation and cytokine expression in BV2 cells, suggesting therapeutic potential for neuroinflammation.
Journal of Neurochemistry · Aug 10, 2017Peer-reviewedNeuroscience