Predictive Patterns of Antidepressant Response from Pre-Treatment Reward Processing using Functional MRI and Deep Learning: Key Results from the EMBARC Randomized Clinical Trial
Kevin P. Nguyen, Cherise Chin Fatt, Alex Treacher, Cooper Mellema, Crystal M. Cooper, Manish K. Jha, Benji T. Kurian, Maurizio Fava M. D, Patrick J. McGrath, Myrna M. Weissman, Mary Louise Phillips, Madhukar H. Trivedi, Albert Montillo
This paper uses deep learning on pre-treatment reward processing fMRI and clinical data to predict antidepressant outcomes, achieving up to 37% variance explained and remission prediction with NNT 2-4.
Biological Psychiatry · Mar 1, 2022Peer-reviewedBioinformatics