All-trans Retinoic Acid Regulates miR-106a-5p Inhibition of Autophagic in Developing Cleft Palates
Lungang Shi, Yan Liang, Lijing Yang, Binchen Li, Binna Zhang, Congyuan Zhen, Jufeng Fan, Shijie Tang
This study shows that all-trans retinoic acid disrupts MEPM cell pluripotency and osteogenic differentiation via miR-106a-5p targeting PTEN, leading to cleft palate development.
bioRxiv · Nov 5, 2020 · PreprintDevelopmental Biology