Early Immune Hypoactivation and Persistent Innate Reprogramming Characterize Chronic Chikungunya Disease
Lien De Caluwé, Candice Bohaud, Borita Heng, Sokchea Lay, Sopheak Sorn, Sreymom Ken, Alvino Maestri, Veasna Duong, Sowath Ly, Giorgio Gonnella, Tineke Cantaert
This study identifies early innate immune hypoactivation and persistent innate immune remodeling in chronic chikungunya patients through longitudinal single-cell RNA sequencing and immune profiling.
bioRxiv · Jun 26, 2026 · PreprintImmunology