Identifying indels from WGS short reads of haploid genomes distinguishes variant-calling algorithms
Yee Mey Seah, Mary K. Stewart, Daniel R. Hoogestraat, Molly Ryder, Brad T. Cookson, Stephen J. Salipante, Noah G. Hoffman
The paper evaluates variant-calling algorithms for identifying indels in haploid bacterial genomes using synthetic reads and finds that high-quality soft-clipped reads improve detection of medium-length indels.
Journal of Clinical Microbiology · Jul 10, 2023Peer-reviewedBioinformatics