The aging human brain exhibits reduced cerebrospinal fluid flow during sleep due to both neural and vascular factors
Sydney M. Bailes, Stephanie D. Williams, Baarbod Ashenagar, Joseph P. Licata, Massinissa Y. Bosli, Brandon J. Dormes, Hannah J. Yun, Dabriel Zimmerman, Alejandra Hernandez Moyers, David H. Salat, Laura D. Lewis
This study shows that aging reduces cerebrospinal fluid flow during sleep, linked to neural and vascular changes, and associated with gray matter atrophy.
bioRxiv · Feb 22, 2025 · PreprintNeuroscience