Population Genetic Analysis of the DARC Locus (Duffy) Reveals Adaptation from Standing Variation Associated with Malaria Resistance in Humans
Kimberly F. McManus, Angela Taravella, Brenna Henn, Carlos D. Bustamante, Martin Sikora, Omar E. Cornejo
The paper analyzes the DARC locus in humans to show strong selection on the FY*O allele associated with malaria resistance, with a selection coefficient of 5% and a TMRCA of 42 kya.
PLOS Genetics · Mar 10, 2017Peer-reviewedGenomics