Multiomic and Spatial Profiling of Colorectal Tissue Reveals Viral Persistence and Immune Dysregulation in Long COVID
Brian LaFranchi, David P. Maison, Joanna Vinden, Antonio E. Rodríguez, Ali Tout, Lilian Grimbert, Emanuel Velazquez, Urmila Vudali, Belen E. Altamirano Poblano, Thomas Dalhuisen, Javier Cattle, Tony R. Figueroa, Yuki Fudotan, Michael Luna, Dylan Ryder, , Timothy J. Henrich
This study uses multiomic and spatial profiling of colorectal tissue and blood to show that Long COVID is linked to immune dysregulation and viral persistence, with stronger signals in tissue than blood.
bioRxiv · Aug 10, 2026 · PreprintImmunology