Improving Consistency in Colorectal Cancer Genetic Risk Assessment and Return of Results Through an Integrated Polygenic Risk Score
Huy Tran, Ashley J Mulford, Jun Wei, Zhuqing Shi, Annabelle Ashworth, S. Lilly Zheng, Brian T Helfand, Peter J Hulick, Allison DePersia, Grace Suh, Blake Jones, Alan R Sanders, Jianfeng Xu
This paper develops a stable polygenic risk score for colorectal cancer by integrating multiple existing scores, improving individual-level risk classification consistency without sacrificing population-level performance.
medRxiv · Nov 9, 2026 · PreprintGenetic & Genomic Medicine