Robust Prediction of Enzyme Variant Kinetics with RealKcat
Karuna Anna Sajeevan, Abraham Osinuga, B. Arunraj, Sakib Ferdous, Nabia Shahreen, Mohammed Sakib Noor, Shashank Koneru, Laura Mariana Santos-Correa, Rahil Salehi, Niaz Bahar Chowdhury, Randy Aryee, Brisa Calderon-Lopez, Supantha Dey, Ankur Mali, Rajib Saha, Ratul Chowdhury
RealKcat predicts enzyme kinetics from sequence using a curated dataset and embeddings, showing sensitivity to catalytic mutations and robustness across evaluations.
PNAS Nexus · Sep 16, 2026Peer-reviewedSystems Biology