ERK plays a conserved dominant role in pancreas cancer cell EMT heterogeneity driven by diverse growth factors and chemotherapies
Michelle C. Barbeau, Brooke A. Brown, Sara J. Adair, Todd W. Bauer, Matthew J. Lazzara
The paper identifies ERK as a dominant driver of EMT heterogeneity in pancreas cancer cells using mutual information modeling and imaging, showing its role is independent of MEK inhibition and growth factors.
bioRxiv · Feb 8, 2025 · PreprintSystems Biology