Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer
A. Hosseini, H. T. Lindholm, R. Chen, P. Mehdipour, S. A. Marhon, C. A. Ishak, D. D. De Carvalho
The paper identifies XRN1 as a dependency in cancer cells that control dsRNA stress through viral mimicry, revealing therapeutic opportunities.
bioRxiv · Mar 30, 2023Cell Biology